کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10815187 | 1058457 | 2014 | 12 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Disordered hepcidin-ferroportin signaling promotes breast cancer growth
ترجمه فارسی عنوان
سیگنال هپسایدین-فرتروپورتین اختلال ایجاد کننده رشد سرطان پستان است
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کلمات کلیدی
DCF-DADeferoxamineMFPSDABPBSFACSLIPABSFACferroportinNACDFOH&E - H & EN-acetyl-cysteine - N-استیل سیستئینROS - ROSantibodies - آنتی بادی هاIron - آهنFerric Ammonium Citrate - آهن آمونیوم سیتراتLabile iron pool - استخر چربintraperitoneal injection - تزریق داخل صفاقیIntravenous injection - تزریق داخل وریدیdiaminobenzidine - دیامینو بنزیدینBreast cancer - سرطان پستانfluorescence activated cell sorting - فلورسانس سلول فعال فعال سلولPhosphate-buffered saline - محلول نمک فسفات با خاصیت بافریHematoxylin and Eosin - هماتوکسیلین و ائوزینHepcidin - هپسیدین Propidium iodide - پروتئین یدیدcalcein acetoxymethyl ester - کلسین اتوکسی متیل استرReactive oxygen species - گونههای فعال اکسیژن
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
چکیده انگلیسی
Iron homeostasis is strictly governed in mammals; however, disordered iron metabolism (such as excess iron burden) is recognized as a risk factor for various types of diseases including cancers. Burgeoning evidence indicates that the central signaling of iron homeostasis, the hepcidin-ferroportin axis, is misregulated in cancers. Nonetheless, the mechanisms of misregulated expression of iron-related genes along this signaling in cancers remain largely unknown. In the current study, we found increased levels of serum hepcidin in breast cancer patients. Reduction of hepatic hepcidin through administration of heparin restrained tumorigenic properties of breast tumor cells. Mechanistic investigation revealed that increased iron, bone morphogenetic protein-6 (BMP6) and interleukin-6 (IL-6) jointly promoted the synthesis of hepatic hepcidin. Tumor hepcidin expression was marginally increased in breast tumors relative to adjacent tissues. In contrast, tumor ferroportin concentration was greatly reduced in breast tumors, especially in malignant tumors, compared to adjacent tissues. Elevation of ferroportin concentration inhibited cell proliferation in vitro and in vivo by knocking down tumor hepcidin expression. Additionally, increased IL-6 was demonstrated to jointly enhance the tumorigenic effects of iron through enforcing cell growth. Our combined data overall deciphered the machinery that altered the hepcidin-ferroportin signaling in breast cancers. Thus, targeting the hepcidin-ferroportin signaling would represent a promising therapeutics to restrain breast cancer growth.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cellular Signalling - Volume 26, Issue 11, November 2014, Pages 2539-2550
Journal: Cellular Signalling - Volume 26, Issue 11, November 2014, Pages 2539-2550
نویسندگان
Shuping Zhang, Yue Chen, Wenli Guo, Lin Yuan, Daoqiang Zhang, Yong Xu, Elizabeta Nemeth, Tomas Ganz, Sijin Liu,