Feedforward and feedback regulation of the MAPK and PI3K oscillatory circuit in breast cancer

► This is the first observation of oscillations in MAPK/PI3K signalling in breast cancer cells. ► A combined experimental and computational approach reveals likely regulatory models. ► These include receptor overexpression, transcriptional control, and pathway crosstalk. ► The core transcriptional regulatory motif responsible for oscillations is enriched for DUSPs. ► The study highlights the benefits of using a combined theoretical and experimental approach.