Deletion of Gremlin1 increases cell proliferation and migration responses in mouse embryonic fibroblasts

►Generation of grem1−/− mouse embryo fibroblasts. ►Grem1−/− cells have elevated rates of growth and migration. ►Grem1−/− cells have increased levels of phospho-Smad1/5/8. ►Grem1−/− cells have reduced levels of phospho-p42/44 ERK.