Spermine, a molecular switch regulating EGFR, integrin β3, Src, and FAK scaffolding

► EGF transactivates integrin β3, recruits Src and FAK during migration. ► Spermine inhibits the EGFR interaction with Src and prevents migration. ► Spermine binds the SH2 domain of Src and prevents EGF-induced migration.