Molecular mechanisms of feedback inhibition of protein kinase A on intracellular cAMP accumulation

► First topical overview of feedback inhibition in the yeast cAMP-PKA pathway. ► First comparison between feedback inhibition in yeast and mammalian cells. ► cAMP phosphodiesterases are best established targets of feedback inhibition. ► Adenylate cyclase may be the elusive main target of feedback inhibition in yeast.