A novel role for TPX2 as a scaffold and co-activator protein of the Chromosomal Passenger Complex

► TPX2 acts as a co-activator protein for Aurora B kinase. ► TPX2 serves as a scaffold protein for assembly of the Chromosomal Passenger Complex. ► Overexpression of TPX2 B causes mitotic defects that reflect Aurora B inhibition. ► The levels of TPX2 correlate with Aurora B activity in pancreatic cancer cells.