Wogonin induces apoptosis by activating the AMPK and p53 signaling pathways in human glioblastoma cells

► Glioblastoma multiforme (GBM) is the most common malignant brain tumor in adults. ► Wogonin-induced apoptosis in GBM cells via ROS-AMPK-P53. ► Wogonin might be useful as a human GBM chemopreventive or therapeutic agent.