The macrophage response towards LPS and its control through the p38MAPK-STAT3 axis

► Summary of LPS-induced signaling in macrophages. ► Focuses on the role of the p38MAPK-STAT3 axis for control of the macrophage response. ► Discussion of the relevance of the MK2 and MK3 for LPS signaling in macrophages. ► Summary of the mechanisms involved in LPS-induced cytokine secretion by macrophages.