Tumor suppressor BLU enhances pro-apoptotic activity of sMEK1 through physical interaction

► BLU directly interacts with sMEK1, a regulatory subunit of protein phosphatase 4. ► Binding activity was confirmed by the BLU-dependent increase of sMEK1 expression. ► BLU can mediate the pro-apoptotic activity via the induction of sMEK1 expression.