IKK-β mediates chemoresistance by sequestering FOXO3; A critical factor for cell survival and death

► FOXO3 contributes to chemoresistance in breast cancer cells. ► Silencing of FOXO3 causes chemoresistance and promotes proliferation. ► Protein levels of FOXO3 and IKK-β are crucial for apoptosis and autophagy induction. ► IKK-β is directly involved in the regulation of FOXO3 and chemoresistance.