Lysophosphatidic acid increases soluble ST2 expression in mouse lung and human bronchial epithelial cells

► LPA induces sST2 gene expression. ► NF-κB and AP-1 pathways regulate sST2 release. ► Histone acetylation regulates sST2 gene expression. ► sST2 protects LPS-induced epithelial barrier disruption.