Involvement of store-operated calcium signaling in EGF-mediated COX-2 gene activation in cancer cells

► Colorectal cancer (CRC) patients whose tumor tissues highly expressed both EGFR and COX-2. ► EGF-mediated COX-2 activation was prevented by 2-APB, a store-operated Ca2+ channel inhibitor. ► siRNA against ORAI1 or STIM1 showed significant inhibitory effects on EGF-mediated COX-2 expression.