A proteomic approach in the study of an animal model of Parkinson's disease

The proteomic study of 6-OHDA-induced lesions in the nigrostriatial pathway allowed us to identify two proteins, α-enolase and β-actin, showing increased levels in the 6-OHDA-lesioned brain tissues compared to control. Previous studies described the same proteins as oxidized and proteins in Alzheimer's disease (AD) brain. Our preliminary data could mirror those results pointing out a common mechanism of neurodegenerative diseases.