Expansion of the silkworm GMC oxidoreductase genes is associated with immunity

► The 43 GMC genes were identified in the silkworm genome. ► The silkworm GMC genes experienced a large expansion. ► At least 24 of the 43 silkworm GMC genes were differently transcribed and expressed. ► RNAi of the induced GMCβ genes reduced the survival rate of the infected silkworm.