کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10825109 | 1063341 | 2005 | 18 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
A triterpene oleanolic acid conjugate with 3-hydroxyflavone derivative as a new membrane probe with two-color ratiometric response
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کلمات کلیدی
MLVFOTESIPTEYPC3HF3-Hydroxychromone3-hydroxyflavone - 3-هیدروکسی فلاونmultilamellar vesicles - vesicles multilamellarsphingomyelin - اسفنگومیلینOleanolic acid - اسید اولانیولیکIntramolecular charge transfer - انتقال اتمی مولکولیExcited-state intramolecular proton transfer - انتقال پروتون بین مولکولی تحریک شدهegg yolk phosphatidylcholine - زرده تخم مرغ فسفاتیدیل کولینICT - فناوری اطلاعات و ارتباطات Fluorescence probe - پروب فلورسانس
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: A triterpene oleanolic acid conjugate with 3-hydroxyflavone derivative as a new membrane probe with two-color ratiometric response A triterpene oleanolic acid conjugate with 3-hydroxyflavone derivative as a new membrane probe with two-color ratiometric response](/preview/png/10825109.png)
چکیده انگلیسی
We report on the synthesis by coupling of a triterpenoid oleanolic acid with 4â²-diethylamino-3-hydroxyflavone (FE) to produce an environment-sensitive biomembrane probe with two-band ratiometric response in fluorescence emission. The synthesized compound (probe FOT) was tested in a series of model solvents and demonstrated the response to solvent polarity and intermolecular hydrogen bonding very similar to that of parent probe FE. Meantime when incorporated into lipid bilayer membranes, it showed new features differing in response between lipids of different surface charges as well as between glycerophospholipids and sphingomyelin. We observed that in the conditions of coexistence of rafts and non-raft structures the probe is excluded from the rafts.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Biochemical and Biophysical Methods - Volume 64, Issue 1, 29 July 2005, Pages 1-18
Journal: Journal of Biochemical and Biophysical Methods - Volume 64, Issue 1, 29 July 2005, Pages 1-18
نویسندگان
Zeynep Turkmen, Andrey S. Klymchenko, Sule Oncul, Guy Duportail, Gulacti Topcu, Alexander P. Demchenko,