کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10825741 | 1064667 | 2014 | 13 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Longitudinal, quantitative monitoring of therapeutic response in 3D in vitro tumor models with OCT for high-content therapeutic screening
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کلمات کلیدی
SNROFDISpectral domain OCTFD-OCTSD-OCTGFRFWHMECMPDTThree-dimensionalCCDOct - اکتبرImage analysis - تجزیه و تحلیل تصویرoptical frequency domain imaging - تصویربرداری با دامنه نوریOptical coherence tomography - توموگرافی انسجام نوریPhotodynamic therapy - درمان فتودینامیکCharge-Coupled Device - دستگاه متصل شارژnumerical aperture - دیافراگم عددیtime-lapse - زمان گذشتfull width at half maximum - عرض کامل در نیمی از حداکثرPhotosensitizer - عکس حساس کنندهExtracellular matrix - ماتریکس خارج سلولیSignal-to-noise ratio - نسبت سیگنال به نویزTherapeutic response - پاسخ درمانیFour-dimensional - چهار بعدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Longitudinal, quantitative monitoring of therapeutic response in 3D in vitro tumor models with OCT for high-content therapeutic screening Longitudinal, quantitative monitoring of therapeutic response in 3D in vitro tumor models with OCT for high-content therapeutic screening](/preview/png/10825741.png)
چکیده انگلیسی
In vitro three-dimensional models of cancer have the ability to recapitulate many features of tumors found in vivo, including cell-cell and cell-matrix interactions, microenvironments that become hypoxic and acidic, and other barriers to effective therapy. These model tumors can be large, highly complex, heterogeneous, and undergo time-dependent growth and treatment response processes that are difficult to track and quantify using standard imaging tools. Optical coherence tomography is an optical ranging technique that is ideally suited for visualizing, monitoring, and quantifying the growth and treatment response dynamics occurring in these informative model systems. By optimizing both optical coherence tomography and 3D culture systems, it is possible to continuously and non-perturbatively monitor advanced in vitro models without the use of labels over the course of hours and days. In this chapter, we describe approaches and methods for creating and carrying out quantitative therapeutic screens with in vitro 3D cultures using optical coherence tomography to gain insights into therapeutic mechanisms and build more effective treatment regimens.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Methods - Volume 66, Issue 2, 15 March 2014, Pages 299-311
Journal: Methods - Volume 66, Issue 2, 15 March 2014, Pages 299-311
نویسندگان
O.J. Klein, Y.K. Jung, C.L. Evans,