کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10825887 | 1064682 | 2013 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
S-sulfhydration/desulfhydration and S-nitrosylation/denitrosylation: A common paradigm for gasotransmitter signaling by H2S and NO
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کلمات کلیدی
SQRGSNOS-nitrosoglutathioneCBSTSTGSSHBiotin-HPDPMercaptopyruvate sulfurtransferaseSRBCSEETHE1PersulfideMSTMMTScystathionine γ-lyase - cystationine γ-lyaseMS/MS - MS / MSThiol - تیول، مرکاپتانBiotin switch - سوئیچ بیوتینSulfhydration - سولف هیدراتاسیونSulfate reducing bacteria - سولفات کاهش باکتری هاHydrogen sulfide - سولفید هیدروژنsulfhydryl - سولفیدریلCysteine - سیستئینcystathionine β-synthase - سیستاتیونین β-سنتازTandem mass spectrometry - طیف سنجی جرمی پشت سر هم یا متوالیNitric oxide - نیتریک اکسیدCarboxy-PTIO - کربوکسی تحملGlutathione - گلوتاتیون
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Sulfhydryl groups on protein Cys residues undergo an array of oxidative reactions and modifications, giving rise to a virtual redox zip code with physiological and pathophysiological relevance for modulation of protein structure and functions. While over two decades of studies have established NO-dependent S-nitrosylation as ubiquitous and fundamental for the regulation of diverse protein activities, proteomic methods for studying H2S-dependent S-sulfhydration have only recently been described and now suggest that this is also an abundant modification with potential for global physiological importance. Notably, protein S-sulfhydration and S-nitrosylation bear striking similarities in terms of their chemical and biological determinants, as well as reversal of these modifications via group-transfer to glutathione, followed by the removal from glutathione by enzymes that have apparently evolved to selectively catalyze denitrosylation and desulfhydration. Here we review determinants of protein and low-molecular-weight thiol S-sulfhydration/desulfhydration, similarities with S-nitrosylation/denitrosylation, and methods that are being employed to investigate and quantify these gasotransmitter-mediated cell signaling systems.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Methods - Volume 62, Issue 2, 1 August 2013, Pages 177-181
Journal: Methods - Volume 62, Issue 2, 1 August 2013, Pages 177-181
نویسندگان
Changyuan Lu, Adam Kavalier, Eugene Lukyanov, Steven S. Gross,