PPAR gamma activation protects the brain against microvascular dysfunction in sepsis

► Sepsis is a disorder characterized by systemic inflammatory response to an infection. ► Decrease in brain capillary density and increase in leukocyte rolling/adhesion occur. ► PPARγ activation increases capillary density and decreases leukocyte rolling/adhesion. ► PPARγ activation is protective against cerebral microvascular dysfunction in sepsis.