Keywords: ACC; acetyl-CoA carboxylase; ADPH; adipophilin; Akt/PKB; protein kinase B; ALOX5; arachidonate 5-lipoxygenase; BTN1A1; butyrophilin subfamily 1 member a1; CIDEA; cell death-inducing DNA fragmentation factor α-like effector A; COX2; cyclooxygenase 2; DGAT
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Keywords: AHR; aryl hydrocarbon receptor; ALD; alcoholic liver disease; BAs; bile acids; CAR; constitutive androstane receptor; CARM1; coactivator associated arginine methyltransferases 1; CBP/P300; CREB-binding protein/p300; CYP27A1/Cyp27a1; sterol 27α-hydroxylas
Keywords: CFU; colony forming unit; DAP; daptomycin; DMSO; dimethyl sulfoxide; EUCAST; European Committee on Antimicrobial Susceptibility Testing; GMO; genetically modified organism; LZD; linezolid; MRSA; methicillin resistant Staphylococcus aureus; MSSA; methicill
Keywords: 27-HC; 27-Hydroxycholesterol; 3PO; 3-(3-pyridinyl)-1-(4-pyridinyl)-2-propen-1-one; ABCG1; ATP-binding cassette subfamily G1; ACBA1; ATP-binding cassette subfamily A1; ACC1; Acetyl-Co-A carboxylase-1; AKAP4; A-kinase anchoring protein 4; ALDO; Aldolase; AM
Keywords: Endometrial cancer; insulin-sensitizing agents; metformin; secretagogues; population-based; AMPK; activated protein kinase; ISA; insulin-sensitizing agent; PC; principal component; PCA; principal components analysis; PCOS; polycystic ovary syndrome; TZD;
Keywords: PPAR; peroxisome proliferator-activated receptor; TZD; thiazolidinedione; ETYA; eicosatetraynoic acid; MTT; 3-(4,5-Dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium bromide; AAALAC; American Association for the Accreditation of Laboratory Animal Care; Cer
Keywords: DILI; drug induced liver injury; hES-HLCs; hepatocyte-like cells derived from human embryonic stem cells; APAP; acetaminophen; TZD; thiazolidinedione; TNF; tumor necrosis factor; ÎL; interleukin; IFN; interferon; PHHs; primary human hepatocytes; hES-DE;
Keywords: AGE; advanced glycation end products; AMPK; adenosine monophosphate-activated protein kinase; AngII; angiotensin II; CKD; chronic kidney disease; CRP; C-reactive protein; CT; computed tomography; DNA; deoxyribonucleic acid; ERS; extracellular-regulated pr
Keywords: 5-HT(2B); 5-hydroxytryptamine 2B receptor; ACE; angiotensin-converting enzyme; AMPK; AMP-activated protein kinase; ARB; AT1R blocker; ASK1; apoptosis signal-regulating kinase 1; AT1R; angiotensin II type 1 receptor; ATX; autotaxin; BDL; bile duct ligation
Keywords: AgRP; agouti-related peptide; ARC; arcuate; CRF; corticotropin releasing factor; DDC; dopa decarboxylase; GLUT1, 2, 3, and 8, respectively; glucose transporter 1, 2, 3, and 8; IR; insulin receptor; ICV; intracerebroventricular; NPY; neuropeptide Y; NPYr1,
Keywords: Macrophage; Adipose; Inflammation; Obesity; Fibrosis; Insulin; AMPK; AMP-activated protein kinase; ATM; adipose tissue macrophages; CRP; C-reactive protein; DIO; diet-induced obesity; DPP-4; dipeptidyl peptidase-4; FFA; free fatty acids; GLP-1; glucagon-l
Keywords: Type 2 diabetes mellitus; Antidiabetic drugs; Cardiovascular safety; Cardiovascular disease; Cardiovascular outcome trials; A1C; glycated A1c hemoglobin; ACEi; angiotensin converting enzyme inhibitor; ACS; acute coronary syndrome; AHA; American heart asso
Keywords: AAD; antiarrhythmic drug; ACEi; angiotensin-converting enzyme inhibitor; AF; atrial fibrillation; AFFIRM; Atrial Fibrillation Follow-up Investigation of Rhythm Management; ARB; angiotensin receptor blocker; ARIC; Analysis of the Atherosclerosis Risk in Co
Keywords: GLUT; Glucose transporter; T1DM; Type-1 diabetes mellitus; T2DM; Type-2 diabetes mellitus; PKB/Akt; protein kinase B; GSK-3; glycogen synthase kinase-3; PGC-1α; peroxisome proliferator-activated receptor gamma coactivator-1α; FOXO; forkhead box O; VLDL;
Keywords: Glycated albumin; Glycosylated hemoglobin; Glucose lowering medication; Taiwan; Reference range; Atherosclerosis; Prevention; ALT; Alanine aminotransferase; XGI; Alpha-Glucosidase Inhibitor; BG; Biguanides; CRE; Creatinine; DM; Diabetes Mellitus; DPP-4; D
Keywords: diabetes mellitus; insulin; metformin; psoriasis; thiazolidinedione; CI; confidence interval; ICD-9-CM; International Classification of Diseases, Ninth Revision, Clinical Modification; IL; interleukin; LHID; Longitudinal Health Insurance Dataset; NHIRD; N
Keywords: RA; rheumatoid arthritis; DCs; dendritic cells; TolDCs; tolerogenic dendritic cells; NSAIDs; non-steroidal anti-inflammatory drugs; GC; glucocorticoids; DMARDs; disease-modifying anti-rheumatic drugs; TLRs; toll-like receptors; CLRs; cell surface C-type l
Keywords: acne; androgenetic alopecia; combined oral contraceptive pills; cyproterone acetate; drospirenone; hirsutism; insulin-sensitizing drugs; polycystic ovary syndrome; spironolactone; cOCP; combined oral contraceptive pill; CPA; cyproterone acetate; EE; ethin
Keywords: ACAT; acyl-CoA cholesterol acyltransferase; ACC; acetyl CoA carboxylases; ACLY; ATP citrate lyases; ACSL; acyl CoA synthetases long chain family; ADRP; adipose differentiation related protein; AGP; advanced glycation end products; AGPAT; acylglycerophosph
Keywords: Î2-TGZ; Î2-Troglitazone; TGZ; Troglitazone; TZD; Thiazolidinediones; RGZ; Rosiglitazone; 2-DG; 2-deoxyglucose; ER; endoplasmic reticulum; CGZ; Ciglitazone; UPR; unfolded protein response; Cancer; Glucose metabolism; 2-deoxyglucose, Thiazolidinediones; W
Keywords: BMI; Body Mass Index; CHF; Congestive Heart Failure; CI; Confidence Interval; eGFR; estimated Glomerular Filtration Rate; HR; Hazard Ratio; MI; Myocardial infarction; RCT; Randomized Controlled Trial; ROC; Receiver Operating Characteristic; TZD; Thiazolid
Keywords: Macrophage; dendritic cell; lipid; nuclear receptor; retinoid X receptor; retinoic acid receptor; peroxisome proliferator-associated receptor; liver X receptor; vitamin D receptor; rheumatoid arthritis; inflammatory bowel disease; systemic lupus erythemat
5-HT2A-mGlu2/3 receptor complex in rat spinal cord glutamatergic nerve endings: A 5-HT2A to mGlu2/3 signalling to amplify presynaptic mechanism of auto-control of glutamate exocytosis
Keywords: mGlu2/3 receptor; 5-HT2A receptor; Glutamate release; Spinal cord; GPCR crosstalk; Heterocomplex; mGlu2/3; metabotropic glutamate receptor type 2/3; 5-HT2A; serotonin type 2A; [3H]D-Asp; [3H]D-aspartate; CNS; central nervous system; EPSCs; excitatory post
Combining 3D data and traditional soil erosion assessment techniques to study the effect of a vegetation cover gradient on hillslope runoff and soil erosion in a semi-arid catchment
Keywords: CDR; Ratio of 3D-estimated volume of deposition over erosion in channels; CumQ; Cumulative runoff volume (L); CumQ20; Cumulative runoff volume (L) recorded the first 20â¯min of rainfall; CumS; Cumulative soil loss (kg); CumS20; Cumulative soil loss (kg)
The influence of peroxisome proliferator-activated receptor γ (PPARγ) ligands on cancer cell tumorigenicity
Keywords: Cancer cells; PPARγ agonist; PPARγ antagonist; Therapeutic agents; Tumorigenicity; ACC; Acetyl-CoA carboxylase; AKR1B10; Alde-keto reductase 1B10; Alpha-ESA; Alpha-eleostreac acid; ACLY; ATP citrate lyase; BADGE; Bisphenol-A-diglycidyl-etter; CSCs; Canc
Structural basis for differential activities of enantiomeric PPARγ agonists: Binding of S35 to the alternate site
Keywords: PPAR; peroxisome proliferator-activated receptor; LBD; ligand-binding domain; LBP; ligand-binding pocket; TZD; thiazolidinedione; Cdk5; cyclin-dependent kinase 5; SRC-1; steroid receptor coactivator-1; r.m.s.; root-mean-square; Crystal structure; Alternat
Importance of 5/6-aryl substitution on the pharmacological profile of 4ʹ-((2-propyl-1H-benzo[d]imidazol-1-yl)methyl)-[1,1ʹ-biphenyl]-2-carboxylic acid derived PPARγ agonists
Keywords: Peroxisome proliferator-activated receptor γ; Pharmacological profile; Coactivator recruitment; Transactivation assay; Molecular modeling; H; helix; LBD; ligand binding domain; PDB; Protein Data Bank; PPAR; peroxisome proliferator-activated receptor; PPR
DBZ is a putative PPARγ agonist that prevents high fat diet-induced obesity, insulin resistance and gut dysbiosis
Keywords: ACC; acetyl-CoA carboxylase; ADRB; adrenoreceptor beta; BAT; brown adipose tissue; CPT1β; carnitine palmitoyltransferase 1 beta; DBZ; danshensu bingpian zhi; Epi-WAT; epididymal white adipose tissue; FATP; fatty acid transport protein; FAS; fatty acid sy
Indazole-based ligands for estrogen-related receptor α as potential anti-diabetic agents
Keywords: Estrogen-related receptor α; ERRα; Nuclear receptor; Anti-diabetic; Metabolic syndrome; Indazole; Thiazolidenedione; TZD; Insulin resistance; ERR; estrogen-related receptor; ER; estrogen receptor; ERE; estrogen response element; ERRE; estrogen-related r
PPARγ signaling and emerging opportunities for improved therapeutics
Keywords: PPARγ; peroxisome proliferator-activated receptor gamma; TZD; thiazolidinedione; T2DM; type 2 diabetes mellitus; RGZ; rosiglitazone; 15d-PGJ2; 15-deoxy-D12,14-prostanglandin J2; PGC-1α; PPARγ co-activator-1α; RXR; retinoid X receptor; PPRE; peroxisome
Evaluation of selected 3D virtual screening tools for the prospective identification of peroxisome proliferator-activated receptor (PPAR) γ partial agonists
Keywords: Method comparison; Docking; Pharmacophore modeling; Shape-based modeling; 2D-similarity based search; Peroxisome proliferator-activated gamma partial agonists; A; anion; Acc; accuracy; Ar; aromatic feature; AUC; area under the curve; C; cation; DMEM; Dulb
New telmisartan-derived PPARγ agonists: Impact of the 3D-binding mode on the pharmacological profile
Keywords: PPARγ; Transactivation; Cytotoxicity; Binding mode; Molecular modeling; Amax; maximum intrinsic activity; BPO; benzoyl peroxide; DMEM; Dulbecco's modified Eagle medium; LBD; ligand binding domaine; mp; melting point; NBS; N-bromosuccinimide; PPAR; peroxi
The elusive endogenous adipogenic PPARγ agonists: Lining up the suspects
Keywords: NO; nitric oxide; NO2; dioxide radical; O2; superoxide; ONO2â; Â peroxynitrite; 15-dPGJ2; 15-deoxy-Î12,14-prostaglandin J2; AA; arachidonic acid; ADH; alcohol dehydrogenase; AF-1; ligand-independent activation function; AF-2; ligand-dependent activatio
Circulating microRNA-320a and microRNA-486 predict thiazolidinedione response: Moving towards precision health for diabetes prevention
Keywords: miR; microRNA; TZD; thiazolidinedione; HDL-c; high density lipoprotein cholesterol; RT-PCR; reverse transcription polymerase chain reaction; MicroRNA; Insulin resistance; Thiazolidinediones; Biomarkers; Precision health;
Acute exposure of beta-cells to troglitazone decreases insulin hypersecretion via activating AMPK
Keywords: AMPK; AMP-activated protein kinase; TZD; thiazolidinediones; IGT; impaired glucose tolerance; IFG; impaired fasting glucose; GSIS; glucose-stimulated insulin secretion; ACC; acetyl-CoA carboxylase; PPARγ; peroxisome proliferator-activated receptor γ; sh
Design, synthesis, in silico molecular docking and biological evaluation of novel oxadiazole based thiazolidine-2,4-diones bis-heterocycles as PPAR-γ agonists
Keywords: 2,4-Thiazolidinedione; 1,3,4-Oxadiazole; Antidiabetic; PPAR-γ; Hepatotoxicity; Cardiotoxicity; TZD; thiazolidinediones; STZ; streptozotocin; ALT; alanine transaminase; AST; aspartate transaminase; ALP; alkaline phosphatase; RT; reverse transcription; PCR
Discovery of 3-(4-methanesulfonylphenoxy)-N-[1-(2-methoxy-ethoxymethyl)-1H-pyrazol-3-yl]-5-(3-methylpyridin-2-yl)-benzamide as a novel glucokinase activator (GKA) for the treatment of type 2 diabetes mellitus
Keywords: Type 2 diabetes mellitus (T2DM); Glucokinase activator (GKA); GK; glucokinase; GKA; glucokinase activator; SU; sulfonylurea; DPP-4; dipeptidyl peptidase-4; TZD; thiazolidinedione; SGLT2; sodium-glucose co-transporter 2; GSIS; glucose-stimulated insulin se
Research ArticleCell-specific PPARγ deficiency establishes anti-inflammatory and anti-fibrogenic properties for this nuclear receptor in non-parenchymal liver cells
Keywords: PPARγ; peroxisome proliferator-activated receptor γ; TZD; thiazolidinediones; TNF-α; tumor necrosis factor α; IL; interleukin; HSCs; hepatic stellate cells; NAFLD; non-alcoholic fatty liver disease; CCl4; carbon tetrachloride; LPS; lipopolysaccharide;
Stimulation of mitochondrial oxidative capacity in white fat independent of UCP1: A key to lean phenotype
Keywords: ACC; acetyl-CoA carboxylase; AMPK; AMP-activated protein kinase; aP2-Ucp1 mice; transgenic mice expressing UCP1 gene from the aP2 gene promoter; AA; arachidonic acid; ATM; adipose tissue macrophages; BAT; brown adipose tissue; BCAA; branched-chain amino a
PPAR gamma activation protects the brain against microvascular dysfunction in sepsis
Keywords: PPARγ; peroxisome proliferator-activated receptor gamma; CLP; cecal ligation and puncture; TZD; thiazolidinediones;
Polymorphisms in the IRSâ1 and PPAR-γ genes and their association with polycystic ovary syndrome among South Indian women
Keywords: PCOS; polycystic ovary syndrome; IRS-1; insulin receptor substrate-1; PPAR-γ; peroxisome proliferator-activated receptor-γ; T2DM; type-2 diabetes mellitus; TZD; thiazolidinediones; INSR; insulin receptor; ESHRE; European Society of Human Reproduction an
Early induction of a brown-like phenotype by rosiglitazone in the epicardial adipose tissue of fatty Zucker rats
Keywords: Rosiglitazone; Epicardial adipose tissue; Fatty rat; TZD; thiazolidinedione; RSG; rosiglitazone; TG; triglycerides; PPARγ; peroxisome proliferator-activated receptor gamma; RXR; retinoid X receptor; CEBP; CCAAT enhancer binding protein; RAT; retroperiton
PPARs: Fatty acid sensors controlling metabolism
Keywords: AF; activation function; AMPK; AMP-activated protein kinase; BAT; brown adipose tissue; C/EBPα; CCAAT-enhancer binding protein α; DBD; DNA binding domain; FA; fatty acid; FAO; FA oxidation; HAT; histone acetyl transferase; HFD; high fat diet; GSIS; gluc
PharmacotherapyOriginal researchSafety of Exenatide Once Weekly in Patients With Type 2 Diabetes Mellitus Treated With a Thiazolidinedione Alone or in Combination With Metformin for 2 Years
Keywords: exenatide; GLP-1 receptor agonist; metformin; glucose control; HbA1c; type 2 diabetes mellitus; TZD;
Regulation of NAD(P)H oxidases by AMPK in cardiovascular systems
Keywords: 7-KC; 7-ketocholesterol; AAA; abdominal aortic aneurysm; AICAR; 5â²-aminoimidazole-4-carboxamide ribonucleoside; AMPK; adenosine monophosphate-activated protein kinase; AngII; angiotensin II; ApoE; apolipoprotein E; BH4; 5,6,7,8-tetrahydrobiopterin; CaMK
The Diagnosis and Management of Non-alcoholic Fatty Liver Disease: Practice Guideline by the American Gastroenterological Association, American Association for the Study of Liver Diseases, and American College of Gastroenterology
Keywords: NAFLD; Nonalcoholic Fatty Liver Disease; NAFL; Nonalcoholic Fatty Liver; NASH; Nonalcoholic Steatohepatitis; T2DM; Type 2 Diabetes Mellitus; AST; Aspartate Aminotransferase; ALT; Alanine Aminotransferase; HOMA; Homeostatic Model Assessment; RCT; Randomize
Role of Obesity and Lipotoxicity in the Development of Nonalcoholic Steatohepatitis: Pathophysiology and Clinical Implications
Keywords: Insulin Resistance; NAFLD; Fatty Liver; Type 2 Diabetes Mellitus; BMI; body mass index; CIMT; carotid-intima medial thickness; CV; cardiovascular; CVD; cardiovascular disease; FFA; free fatty acid; IL; interleukin; MRS; magnetic resonance imaging and spec
Features, Diagnosis, and Treatment of Nonalcoholic Fatty Liver Disease
Keywords: Diagnosis; Epidemiology; Cancer Risk; Mechanisms; ALT; alanine aminotransferase; APOC3; apolipoprotein C3; ARFI; acoustic radiation force impulse elastography; AST; aspartate aminotransferase; ATF6; activating transcription factor-6; AUROC; area under the
Brazilian propolis-derived components inhibit TNF-α-mediated downregulation of adiponectin expression via different mechanisms in 3T3-L1 adipocytes
Keywords: aP2; adipocyte fatty acid-binding protein 4; EMM; molecular mechanics energy; FBS; fetal bovine serum; JNK; c-Jun-NH2-terminal kinase; MAPK; mitogen-activated protein kinase; MKK; mitogen-activated protein kinase kinase; MM-PBSA; molecular mechanics Poiss
PPARγ stabilizes HO-1 mRNA in monocytes/macrophages which affects IFN-β expression
Keywords: 15d-PGJ2; 15-deoxy-Î12,14-prostaglandin J2; CRE; causes recombination; CO; carbon monoxide; CHX; cycloheximide; d/n; dominant negative; DPI; diphenyliodonium; HE; hydroethidine; HO-1; heme oxygenase-1; LPS; lipopolysaccharide; LysM; lysozyme M; mac; macr