کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8737303 | 1591328 | 2018 | 23 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
An in vitro evaluation of the efficacy of tedizolid: implications for the treatment of skin and soft tissue infections
ترجمه فارسی عنوان
ارزیابی درونمایه اثربخشی تدی زولید: پیامدهای درمان عفونت های پوستی و بافت نرم
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کلمات کلیدی
PBSEUCASTSSTITZDMSSAGMODAPMICCFUDMSO - DMSOMHb - MHBgenetically modified organism - ارگانیزم اصلاح شده ژنتیکیMethicillin sensitive Staphylococcus aureus - استافیلوکوک اورئوس حساس به متی سیلینMRSA - استافیلوکوک اورئوس مقاوم به متی سیلین یا MRSA Methicillin resistant Staphylococcus aureus - استافیلوکوک اورئوس مقاوم به متیسیلینStaphylococcus - استافیلوکوکهاBiofilm - بیوفیلمTedizolid - تدیزیلدMinimum inhibitory concentration - حداقل غلظت مهاریDaptomycin - داپتومایسینDimethyl sulfoxide - دیمتیل سولفواکسیدSkin and soft tissue infection - عفونت بافت پوست و نرمSkin and soft tissue infections - عفونت های پوستی و بافت نرمPhosphate buffered saline - فسفات بافر شورlinezolid - لینزولیدMueller-Hinton broth - مولر-هینتون بوثهVAN - وانVancomycin - وانکومایسینVISA - ویزاcolony forming unit - کلنی واحد تشکیلEuropean Committee on Antimicrobial Susceptibility Testing - کمیته اروپایی برای آزمایش حساسیت ضد میکروبی
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
میکروبیولوژی و بیوتکنولوژی کاربردی
چکیده انگلیسی
Skin and soft tissue infections (SSTI) are among the most commonly occurring infections and evidence suggests that these are increasing world-wide. The aetiology is diverse, but Staphylococcus aureus predominate and these are often resistant to antimicrobials that were previously effective. Tedizolid is a new oxazolidinone-class antibacterial indicated for the treatment of adults with SSTI caused by Gram-positive pathogens, including S. aureus. The aim of this study was to evaluate the in vitro efficacy of tedizolid in comparison to other clinically used antibacterials against antibiotic sensitive- and resistant-staphylococci, grown in planktonic cultures and as biofilms reflecting the growth of the microorganism during episodes of SSTI. Against a panel of 66 clinical staphylococci, sensitivity testing revealed that a lower concentration of tedizolid was required to inhibit the growth of staphylococci compared to linezolid, vancomycin and daptomycin; with the tedizolid MIC50 being 8-fold (S. aureus) or 4-fold (S. epidermidis) below that obtained for linezolid. In addition, cfr+ linezolid-resistant strains remained fully susceptible to tedizolid. Against S. aureus biofilms, 10ÃMIC tedizolid was superior or comparable with 10ÃMIC comparator agents in activity, and superior to 10ÃMIC linezolid against those formed by S. epidermidis (65 vs. 33% reduction, respectively). Under flow-conditions both oxazolidinones at 10ÃMIC statistically out-performed vancomycin in their ability to reduce the viable cell count within a S. aureus biofilm with fewer the 12% of cells surviving compared to 63% of cells. In conclusion, tedizolid offers a realistic lower-dose alternative agent to treat staphylococcal SSTI, including infections caused by multi-drug resistant strains.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Diagnostic Microbiology and Infectious Disease - Volume 91, Issue 1, May 2018, Pages 93-97
Journal: Diagnostic Microbiology and Infectious Disease - Volume 91, Issue 1, May 2018, Pages 93-97
نویسندگان
Pierre Delpech, Muna ALeryan, Brian Jones, Curtis Gemmell, Sue Lang,