کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5823439 1118327 2014 34 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Energy restriction mimetic agents to target cancer cells: Comparison between 2-deoxyglucose and thiazolidinediones
ترجمه فارسی عنوان
عوامل محدود کننده انرژی محدود کننده برای هدف قرار دادن سلول های سرطانی: مقایسه بین 2-دکوزید گلوکز و تیازولیدیدون ها
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی داروشناسی
چکیده انگلیسی
The use of energy restriction mimetic agents (ERMAs) to selectively target cancer cells addicted to glycolysis could be a promising therapeutic approach. Thiazolidinediones (TZDs) are synthetic agonists of the nuclear receptor peroxisome proliferator-activated receptor (PPAR)γ that were developed to treat type II diabetes. These compounds also display anticancer effects which appear mainly to be independent of their PPARγ agonist activity but the molecular mechanisms involved in the anticancer action are not yet well understood. Results obtained on ciglitazone derivatives, mainly in prostate cancer cell models, suggest that these compounds could act as ERMAs. In the present paper, we introduce how compounds like 2-deoxyglucose target the Warburg effect and then we discuss the possibility that the PPARγ-independent effects of various TZD could result from their action as ERMAs.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochemical Pharmacology - Volume 92, Issue 1, 1 November 2014, Pages 102-111
نویسندگان
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