Rosuvastatin improves pulse wave reflection by restoring endothelial function

► In the crossover study patients were assigned to receive rosuvastatin and placebo. ► Pulse wave analysis and basal NO activity as endothelial function were assessed. ► Rosuvastatin improves basal NO activity by lipid- and non-lipid-dependent effects. ► Improved basal NO activity is a determinant of pulse wave reflection and PPA.