Recommendations for the use of sapropterin in phenylketonuria

► Metabolic experts convened to draft recommendations for sapropterin use in PKU. ► Our aim is to provide a uniform and practical approach for sapropterin use in PKU. ► Recommendations are based on extensive clinical experience and current evidence. ► Guidance from patient selection to long-term management of patients is presented. ► This could serve as a useful adjunct to future national consensus statements.