A novel application of pattern recognition for accurate SNP and indel discovery from high-throughput data: Targeted resequencing of the glucocorticoid receptor co-chaperone FKBP5 in a Caucasian population

► Pattern recognition approach produces higher accuracy than current methods. ► We are able to detect rare variants and indels. ► We show perturbations in a critical binding site of FKBP5 mRNA. ► We provide possible explanation for individual differences in GR sensitivity.