The phosphorescence oxygen analyzer as a screening tool for disorders with impaired lymphocyte bioenergetics

► The phosphorescence oxygen analyzer permits non-invasive, preliminary assessment of cellular bioenergetics. ► Oxygen analyzer could be used as screening tool for mitochondrial DNA depletion syndrome. ► Lymphocytes are a good source for measuring cellular respiration. ► Limitations of oxygen analyzer include the need for fresh blood samples and the phenomenon of heteroplasmy.