SIRT1 is associated with a decrease in acute insulin secretion and a sex specific increase in risk for type 2 diabetes in Pima Indians

► Variation in SIRT1 is associated with insulin secretion and increased risk for T2D. ► The association with type 2 diabetes is more prominent in Pima Indian women. ► Expression of SIRT1 in adipose tissue is correlated with BMI and percent body fat.