Association of ACACB polymorphisms with obesity and diabetes

► Tag SNPs of the Acetyl-CoA carboxylase beta gene (ACACB) were studied in women. ► One SNP was significantly associated with morbid obesity. ► Two SNPs were associated with type 2 diabetes, independently of BMI. ► EMSA suggested the binding of glucocorticoid receptor and serum response factor. ► ACACB polymorphisms appear to influence the risk of obesity and type 2 diabetes.