Polymorphisms of endothelial nitric oxide synthase gene in systolic heart failure: An haplotype analysis

► This study evaluates eNOS haplotypes on heart failure susceptibility and prognosis. ► We conducted a case-control and a cohort study (316 patients and 360 controls). ► Haplotype frequencies differ only in African-Brazilians. ► -786C/4b/Asp298 African-Brazilian patients have a better prognosis.