The role of nitric oxide in prostaglandin biology; update

► Nitric oxide regulates prostaglandin synthesis. ► Nitric oxide activates cyclooxygenase2 activity via S-nitrosylation. ► Peroxinitrite inactivates cyclooxygenase1/2 via Tyrosine nitration. ► Interaction of Peroxinitrite and heme in cyclooxygenase can activate their activity.