کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10835217 | 1066060 | 2005 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The solid-state molecular structure of the S-nitroso derivative of l-cysteine ethyl ester hydrochloride
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: The solid-state molecular structure of the S-nitroso derivative of l-cysteine ethyl ester hydrochloride The solid-state molecular structure of the S-nitroso derivative of l-cysteine ethyl ester hydrochloride](/preview/png/10835217.png)
چکیده انگلیسی
Nitrosation of protein sulfhydryl groups to form thionitrites (S-nitrosothiols) has been reported to be important in the biochemistry of nitric oxide. Such S-nitrosation of protein thiol residues has been shown to alter the function of some proteins. In this brief communication, we report the X-ray crystal structure of S-nitroso-l-cysteine ethyl ester hydrochloride. Two rotamers with respect to the NCCS moiety are present in the crystal: the major rotamer is in the gauche+ conformation, and the minor rotamer is in the rare anti (trans, antiperiplanar) conformation for a cysteinyl compound. Importantly, the CSNO groups for both rotamers are in the syn (cis, synperiplanar) form. To the best of our knowledge, this is the first reported high-resolution solid-state structure of an S-nitroso derivative of a cysteine or cysteinyl-containing compound.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Nitric Oxide - Volume 12, Issue 4, June 2005, Pages 261-266
Journal: Nitric Oxide - Volume 12, Issue 4, June 2005, Pages 261-266
نویسندگان
Jun Yi, Masood A. Khan, Jonghyuk Lee, George B. Richter-Addo,