کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10836897 | 1066449 | 2005 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Central thyrotropin-releasing hormone increases hepatic cyclic AMP through vagal-cholinergic and prostaglandin-dependent pathways in rats
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کلمات کلیدی
6-OHDAEGTA6-HydroxydopaminePMSFethylene glycol-bis-(2-aminoethylether)-N,N,N′,N′-tetraacetic acidcAMP - cAMPEDTA - اتیلن دی آمین تترا استیک اسید Ethylenediaminetetraacetic acid - اتیلینیدامین تتراستیک اسیدtrh - بازارHepatic regeneration - بازسازی کبدAutonomic nervous system - دستگاه عصبی خودمختار یا خودگردان یا اتونومcentral nervous system - سیستم عصبی مرکزیPhenylmethanesulfonyl fluoride - فنیل متیل سولفونیل فلورایدNeuropeptide - نوروپپتیدthyrotropin-releasing hormone - هورمون آزاد کننده تیروتروپین
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Central neuropeptides play roles in many physiologic regulations through the autonomic nervous system. We have demonstrated that central thyrotropin-releasing hormone (TRH), one of neuropeptides, induces a stimulation of hepatic proliferation through vagal-cholinergic pathways. Since cAMP is known to play an important role in the hepatic proliferation, effect of central TRH on hepatic cAMP was investigated. Rats were intracisternally injected with either a TRH analog, RX-77368 (1-100Â ng), or saline. The liver was removed 2-72Â h after the TRH analog and hepatic cAMP content was determined by radioimmunoassay. In some experiments, pretreatment with hepatic vagotomy, atropine methyl nitrate, or 6-hydroxydopamine (6-OHDA) was performed. Hepatic cAMP was dose-dependently increased by intracisternal TRH analog (5-100Â ng) with a peak response occurring 12Â h postinjection. The central TRH-induced increase in hepatic cAMP was abolished by vagotomy, atropine and indomethacin, but not by 6-OHDA. Intravenous injection of the TRH analog (10Â ng) did not affect hepatic cAMP. These results demonstrate that TRH acts in the brain to increase hepatic cAMP through vagal-cholinergic and prostaglandin-dependent pathways, suggesting that central TRH modulates hepatic functions through cAMP-mediated signaling pathways.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Peptides - Volume 26, Issue 9, September 2005, Pages 1573-1579
Journal: Peptides - Volume 26, Issue 9, September 2005, Pages 1573-1579
نویسندگان
Masashi Yoneda, Toru Kono, Hajime Watanobe, Masaya Tamano, Tadahito Shimada, Hideyuki Hiraishi, Kimihide Nakamura,