Antidepressant-like effect of ursolic acid isolated from Rosmarinus officinalis L. in mice: Evidence for the involvement of the dopaminergic system

► Ursolic acid (UA) is a triterpenoid compound isolated from Rosmarinus officinalis. ► UA reduces the the immobility time in the tail suspension test (TST) and forced swimming test. ► UA does not exert psychostimulant effect in the open-field test. ► The effect of UA is mediated by an activation of dopamine D1 and D2 receptors. ► UA administration potentiates the effect of bupropion in the TST.