l-theanine attenuates abstinence signs in morphine-dependent rhesus monkeys and elicits anxiolytic-like activity in mice

► l-theanine attenuated opioid-withdrawal signs in morphine-dependent rhesus monkeys. ► l-theanine had anxiolytic-like effects in the elevated plus maze in naïve mice. ► l-theanine had anxiolytic-like effects in the marble burying assay in naïve mice.