Antagonism of orexin-1 receptors attenuates swim- and restraint stress-induced antinociceptive behaviors in formalin test

► Acute exposure to swim stress reduced formalin-induced nociceptive behaviors. ► Acute exposure to restraint stress reduced formalin-induced nociceptive behaviors. ► Blocking the orexin-1 receptors decreased stress-induced antinociceptive behaviors. ► Naloxone partially decreased the stress induced antinociceptive behaviors.