Morris water maze performance deficit produced by intermittent swim stress is partially mediated by norepinephrine

► Intermittent swim stress (ISS) did produce performance deficits in the MWM. ► Desipramine reduced ISS-induced deficits only in the learning trials of the MWM. ► Reboxetine reduced ISS-induced deficits in acquisition and retrieval in the MWM. ► Clonidine enhanced ISS-induced deficits only in the learning trials of the MWM. ► NE may act as a partial mediator of ISS-induced deficits in MWM performance.