Lack of efficacy of curcumin on neurodegeneration in the mouse model of Niemann-Pick C1

► Curcumin exerts anti-Alzheimer's effect in animal models. ► Niemann-Pick C1 is considered as juvenile Alzheimer's. ► We tested curcumin's effects in Niemann-Pick C1 animal models. ► Four different formulations/dosages had minimal effects.