Adolescent exposure to methylphenidate has no effect on the aversive properties of cocaine in adulthood

► Assessed the effects of adolescent exposure to methylphenidate on later cocaine. ► Adolescent methylphenidate had no effect on aversive properties of later cocaine. ► Methylphenidate attenuated growth rates at the higher of two doses tested. ► Enhanced locomotor activation from cocaine following low dose methylphenidate. ► Reported changes in cocaine following methylphenidate likely mediated by reward.