The novel adenosine A2A antagonist prodrug MSX-4 is effective in animal models related to motivational and motor functions

► MSX-4 is a novel adenosine A2A antagonist prodrug, converted into MSX-2 in vivo. ► MSX-4 reversed the effects of eticlopride on effort-related choice behavior. ► MSX-4 increased locomotion in eticlopride-treated rats. ► MSX-4 suppressed galantamine-induced tremulous jaw movements in rats. ► MSX-4 may be useful for treating parkinsonism and depression.