Post-weaning social isolation and subchronic NMDA glutamate receptor blockade: Effects on locomotor activity and GABA signaling in the rat suggest independent mechanisms

► Assessed whether social isolation (SI) & MK-801 would create a robust animal model of SZ. ► Assessed locomotor activity, GAT-1 & GABAA receptors in the frontal cortex and hipp. ► SI increased activity, GAT-1 & GABAA receptor activity in the frontal cortex. ► MK-801 increased GABAA receptor activity in the hippocampus. ► SI & MK-801 may act through different mechanisms.