Psychopharmacological study of agmatine in behavioral tests of schizophrenia in rodents

► We investigated the effect of agmatine in animal models of schizophrenia. ► Agmatine blocked conditioned avoidance response in rats. ► Agmatine attenuated apomorphine induced climbing in mice.► Agmatine diminished hyperlocomotor activity induced by psychostimulants. ► Our results project agmatine as novel approach in the treatment of schizophrenia.