Recent and remote spatial memory in mice treated with cytosine arabinoside

► Chemotherapy is associated with cognitive impairments in some cancer survivors. ► The etiology of chemotherapy-induced cognitive dysfunction remains unknown. ► Development of animal models may facilitate the search for the underlying mechanisms. ► Mouse and rat models of chemotherapy-induced cognitive dysfunction may differ. ► C57BL/6J mice may be resistant to some types of chemo-induced cognitive decline.