Minocycline produced antidepressant-like effects on the learned helplessness rats with alterations in levels of monoamine in the amygdala and no changes in BDNF levels in the hippocampus at baseline

► Minocycline induced antidepressant-like effects on learned helplessness (LH) rats. ► Infusion of minocycline into the naïve rats did not produce locomotor activation. ► Minocycline induced alterations in monoamines levels in the amygdala of LH rats. ► Minocycline did not restore the reduction of hippocampal BDNF levels of LH rats.