Intra-accumbal NMDA but not AMPA/kainate receptor antagonist attenuates WIN55,212-2 cannabinoid receptor agonist-induced antinociception in the basolateral amygdala in a rat model of acute pain

► Administration of WIN55,212-2 into the BLA dose-dependently induced antinociception. ► Intra-NAc NMDA receptor antagonist decreased the analgesic effect of WIN in the BLA. ► CNQX microinjected into the NAc could not affect the analgesic effect of WIN in BLA. ► Blockade of AMPA/kainate but not NMDA receptors in the NAc produced hyperalgesia.