Alterations on the morphology, nitric oxide synthesis and activity of platelets reproduced in rats as possible biomarkers for depression are reversed by fluoxetine

► Chronic FST in rats allows presence of biomarkers for diagnosis of depression. ► NO/5-HT/morphology as biomarkers for depressive-like behavior in rats platelets. ► Fluoxetine prevents presence of biomarkers for depressive-like behavior in rats.