Cannabinoid CB1 receptor antagonist rimonabant disrupts nicotine reward-associated memory in rats

► Rimonabant disrupted the reconsolidation of nicotine memory. ► Rimonabant blocked reinstatement of nicotine CPP. ► Rimonabant itself did not produce CPP. ► Cannabinoid CB1 receptor may be a potential target for managing nicotine addiction.