Antinociceptive and anti-inflammatory activities of nicotinamide and its isomers in different experimental models

► Nicotinamide exhibits antinociceptive activity in a model of nociceptive pain. ► Nicotinamide exhibits antinociceptive activity in a model of inflammatory pain. ► Nicotinamide exhibits anti-inflammatory activity. ► Isonicotinamide and picolinamide also inhibit nociception and inflammation.