Concentration- and time-dependent behavioral changes in Caenorhabditis elegans after exposure to nicotine

► Nicotine induces profound behavioral responses in Caenorhabditis elegans. ► A low nicotine concentration (0.001 mM) causes a reduction of the movement speed. ► Moderate concentrations (0.01 and 0.1 mM) induce acceleration of the mean speed. ► High doses of nicotine (≥ 1 mM) slow down of the movements or lead to paralysis.