Chronic cocaine self-administration attenuates the anxiogenic-like and stress potentiating effects of the benzodiazepine inverse agonist, FG 7142

► Relapse to cocaine abuse can be elicited by stress. ► Pharmacological stressors can serve as probes in understanding this phenomenon. ► FG 7142 potentiates the stress response of rats to the EPM. ► These effects are absent in cocaine trained rats. ► FG 7142 does not influence extinguished cocaine seeking behavior.