Oral tremor induced by galantamine in rats: A model of the parkinsonian side effects of cholinomimetics used to treat Alzheimer's disease

► Galantamine is a common dementia treatment, but also induces parkinsonian tremor. ► Galantamine induced tremulous jaw movements in rats. ► These tremulous jaw movements occurred largely in the 3-7 Hz frequency range. ► These oral tremors were blocked by adenosine A2A antagonism. ► Adenosine A2A antagonists may be useful for treating galantamine-induced tremor.