Role of GLT-1 transporter activation in prevention of cannabinoid tolerance by the beta-lactam antibiotic, ceftriaxone, in mice

► Beta lactam antibiotics offer neuroprotection by increasing GLT-1 expression. ► Ceftriaxone prevents the development of tolerance and dependence to opioids. ► Cannabinoid tolerance is known to be similar to opioids. ► Ceftriaxone attenuated the development of tolerance to the cannabinoid. ► GLT-1 transporter inhibitor reversed the preventive effect of ceftriaxone.